ScienceAugust 13, 2026

nucleosome

NOO-klee-uh-sohm

Definition

A structural unit of eukaryotic chromosomes consisting of a length of DNA coiled around a core of histone proteins.

Etymology

Derived from the Latin 'nucleus' meaning 'kernel' or 'nut,' combined with the biological suffix '-some' which denotes a body or particle.

In the news

In the article, nucleosomes are described as regulatory factors that block the protein GCN4 from binding to unintended, or 'promiscuous,' sites on minichromosomes. Their presence is essential for maintaining the specificity of genetic interactions.

Nucleosomes and IDRs suppress promiscuous GCN4 binding on minichromosomes

Read the full article ↗

Nature

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