ScienceAugust 13, 2026
promiscuous
pruh-MIS-kyoo-uhs
Definition
Characterized by indiscriminate or random interactions rather than specific, regulated ones.
Etymology
Derived from the Latin 'promiscuus', meaning 'mixed' or 'indiscriminate', formed by the prefix 'pro-' meaning 'forward' and the root 'miscere' meaning 'to mix'.
In the news
In this context, the word describes how the protein GCN4 binds non-specifically or inappropriately to DNA sites it is not intended to regulate. Suppressing this behavior is essential for ensuring precise genetic control.
Nucleosomes and IDRs suppress promiscuous GCN4 binding on minichromosomes
Read the full article ↗Nature