ScienceAugust 13, 2026

promiscuous

pruh-MIS-kyoo-uhs

Definition

Characterized by indiscriminate or random interactions rather than specific, regulated ones.

Etymology

Derived from the Latin 'promiscuus', meaning 'mixed' or 'indiscriminate', formed by the prefix 'pro-' meaning 'forward' and the root 'miscere' meaning 'to mix'.

In the news

In this context, the word describes how the protein GCN4 binds non-specifically or inappropriately to DNA sites it is not intended to regulate. Suppressing this behavior is essential for ensuring precise genetic control.

Nucleosomes and IDRs suppress promiscuous GCN4 binding on minichromosomes

Read the full article ↗

Nature

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