ScienceAugust 13, 2026

remodeler

ree-MOD-uh-ler

Definition

A protein complex that uses ATP energy to alter the structure, spacing, or positioning of nucleosomes on DNA.

Etymology

Derived from the verb remodel, combining the prefix re- (again) and model, originating from Middle French modeler, which stems from the Latin modulus (a measure).

In the news

In the article, remodelers are discussed in the context of how they interact with nucleosomes and intrinsically disordered regions to regulate transcription factor binding.

Nucleosomes and IDRs suppress promiscuous GCN4 binding on minichromosomes

Read the full article ↗

Nature

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